This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. A 3-year well controlled reproductive safety study was conducted in 27 pregnant mares, and compared with 24 untreated control mares. Our experienced and specially qualified team of vets and customer service advisers provide a great … (9); No. It is also commonly used to help maintain pregnancy in mares determined to be at risk of pregnancy loss. Facilitate management of the mare exhibiting prolonged estrus during the transition period. HUMAN WARNINGS: Skin contact must be avoided as Regu-Mate® (altrenogest) Solution 0.22% is readily absorbed through unbroken skin. ● Attainment of regular cyclicity during the transition from winter anestrus to the physiological breeding season. Direct contact with the skin should therefore be avoided. 1989. Squires, E.L., R.K. Shideler, and A.O. ● stallion offspring from treated and control mares showed no difference in sexual behavior. I accidentally spilled about 20 cc of regumate on my arm! Breeding should follow usual procedures for mares in estrus. Remove cover from bottle dispensing tip and connect luer lock syringe (without needle). Treated mares received 2 mL Regu-Mate® (altrenogest) Solution 0.22% /110 lb body weight (2 x dosage recommended for estrus suppression) from day 20 to day 325 of gestation. (9); No. Collapse. Excessive use of a syringe may cause the syringe to stick; therefore, replace syringe as necessary. Facilitate attainment of regular cycles during the transition period from winter anestrus to the physiological breeding season. Available for Android and iOS devices. In addition, this oil based product can penetrate porous gloves. 07498787 The use of a synthetic hormone is often used to aid diagnosis in cases where it is unclear whether or not the behaviour is a symptom of the mare being in oestrous. In filly offspring (all ages) of treated mares, clitoral size was increased. Natural or synthetic gestagen therapy may exacerbate existing low-grade or “smoldering” uterine inflammation into a fulminating uterine infection in some instances. I was considering getting my mare on this, but am worried about the side effects of this.So what sort of side effects can there be and what kind of prescautions do people who give their mares Regumate do to prevent hormone problems? When used as directed on the label, Regu-Mate is usually tolerated well by horses. Daily injections of progesterone (150 mg/mare) or a long-acting progesterone … Updated: 2020-11-27. Taxotere side effects include permanent hair loss, Diabetes drug Invokana lawsuit information, Problems from Essure birth control procedure. Suppression of estrus allows for a predictable occurrence of estrus following drug withdrawal. Manufactured for: Intervet Inc (d/b/a Merck Animal Health), Summit, NJ 07901, Copyright © 2020 Animalytix LLC. Call a physician. Questo è dato a una puledra o cavalla per impedirle di entrare in calore nei momenti cruciali . The chemical structure is: Each mL of Regu-Mate® (altrenogest) Solution 0.22% contains 2.2 mg of altrenogest in an oil solution. Regumate is administered orally at 1ml per 50kg BWt. Long Term Side Effects of Regumate Jun. However, mares with active ovaries (follicles greater than 20 mm in diameter) frequently respond with regular post-treatment estrus cycles. The oil base may also cause complications if swallowed. Mares may be regulated and scheduled either individually or in groups. Regu-Mate® (altrenogest) Solution 0.22% produces a progestational effect in mares. Draw out appropriate volume of Regu-Mate® solution. 8. 106 5556 23 www.wessexequine.co.uk Company no. ... side effects seen in horses. Ovulation will occur 5 to 7 days following the onset of estrus as expected for non-treated mares. Regumate™, a synthetic progesterone, has the effect of stopping a mare from coming into season. Regumate@ is another name for this medication. Pregnant women and others of child bearing age should exercise extreme caution when handling this product. (Note: Do not remove syringe while bottle is inverted as spillage may result.) Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. REGUMATE IN STALLIONS – Effects on Reproductive Performance Patrick M. McCue DVM, PhD, Diplomate American College of Theriogenologists Regumate® or altrenogest is a synthetic progestin approved for suppression of estrus in mares. The information contained in this section is extrapolated from data available on other products of the same pharmacological class that have been used in humans. Effects anticipated are due to the progestational activity of altrenogest. The oral synthetic progestin altrenogest (Regumate Equine, MSD Animal Health) is the only treatment licensed for … WARNING: Regu-Mate® (altrenogest) Solution 0.22% is readily absorbed by the skin. Various synthetic progestins, including altrenogest, when administered to rats during the embryogenic stage of pregnancy at doses manyfold greater than the recommended equine dose caused fetal anomalies, specifically masculinization of the female genitalia. Regumate Side Effects. People with known or suspected estrogen-dependent neoplasia. Consult your pharmacist or physician. Side Effects & Adverse Reactions. ● stallion offspring from treated and control mares showed no differences in seminal volume, spermatozoal concentration, spermatozoal motility, and total sperm per ejaculate. We offer the most comprehensive selection of genuine UK-sourced pet prescription medicines and non-prescription products. Altrenogest should not penetrate intact rubber or impervious gloves; however, if there is leakage (i.e., pinhole, spillage, etc. She would have a seizure around four days prior to her season. For oral use in horses only. Discussion Starter • #1 • Jul 10, 2010. ● mean interovulatory interval from first to second cycle and second to third cycle, mares only. People who should not handle this product include: women who are pregnant or suspect they are pregnant; anyone with throm… Regu-Mate effectively suppresses oestrus in 95 percent of mares after 3 days of treatment through alleviating moodiness and temperament changes caused by the hormone. Vet. What are the side effects of Regu-Mate Solution? Regumate is generally extremely well tolerated by mares, and is highly unlikely to produce any undesirable side effects. Keep this and all other medications out of the reach of children. Vomiting should be supervised by a physician because of possible pulmonary damage via aspiration of the oil base. We comply with the HONcode standard for trustworthy health information -, Warnings and cautions for Regu-Mate Solution, Direction and dosage information for Regu-Mate Solution. McKinnon. To be used with Regumate Dosing Device. Fillies whose mothers received Regu-Mate experienced their first heat cycle earlier than fillies whose mother did not receive the drug. ● after 3 cycles, 11/12 treated mares were pregnant (91.7%) and 4/4 untreated mares were pregnant (100%). Una puledra o cavalla in calore … It can be given daily to a mare early in her season and usually within 3 days it will stop that oestrus. There has been alot of talk if this could damage the sperm/abiltiy to produce viable sperm but, I do not think it has been proven. Regu-Mate® (altrenogest) Solution 0.22% is contraindicated for use in mares having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis). Women who are or suspect they are pregnant. 2. Altrenogest is readily absorbed from contact with the skin. Administer solution directly on the base of the mare’s tongue or on the mare’s usual grain ration. 2: 73-76. I washed it off immediately. Eye Exposure: Immediately flush with plenty of water for 15 minutes. In some cases, Regu-Mate Solution is used for pregnancy maintenance. While the product is not designed for use in mares that are already in foal or that are producing milk, no negative effects have been observed in either the mare or the foal in conjunction with the use of Regumate. To facilitate attainment of regular cycles during the transition phase, mares should be examined to determine the degree of ovarian activity. Trenbolone is reported as an ingredient of Regumate Pig in the following countries: Skin contact must be avoided; protective gloves must be worn when handling this product. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 2. 8, 2015, 10:31 AM I have previously had mares in training on Regumate, but were not with me long enough to see the long term side effects.