It helps in therapeutic drug monitoring. In distribution analysis, 25% of patients had a maximum Tp change greater than 51% and maximum Tt change of 35%.Conclusions: In our population of patients on stable IM T dose, there was a wide mean variation in both Tp (23%) and Tt (17.5%). The asset you are trying to access is locked. I just got back my 6 week bloodwork and ended up lowering T dosage from 60mg e3.5d to 50mg e3.5d. For the free testosterone the average trough was 59.94 +/- 20.60 pmol/L and the peak was 85.17 +/- 32.88 pmol/L. Peak testosterone is then assumed to be about 300 ng/dl above the trough. And, unfortunately, most PCPs are just woefully ignorant in this area. So, we recommend scheduling lab work first thing in the morning. It is responsible for the development of the male external genitalia and secondary sexual characteristics. The goal of this study was to define the variability in T levels in a population of men on IM T. Objective: The vascular effects of fluctuations in testosterone levels within the physiological range in otherwise healthy men are not known. A second half dose is taken two days later. As you can see, despite having healthy trough levels, there was significant variance in his Testosterone level between injections, providing false reassurance of stability. They will even suggest psychotherapy or just ask the man to leave since their “hands are tied”. As mentioned before, we should be looking to achieve stable levels. I can tell the difference between my peak and trough but moreso my Estradiol level. The goal of this study was to define the variability in T levels in a population of men on IM T.Methods: Patients with 3 consecutive Tp and Tt levels available, while on a stable dose and interval of IM T cypionate were analyzed. Also testosterone is converted to inactive metabolites in the liver, adipose tissue, muscle and kidney. I would be happy to assist you further, if you need any more information. Mean Tp variance was 210±99ng/dl representing a 23% change from cycle to cycle. They do weekly injections of testosterone cypionate. Figure 14.10 shows some data for 100mg injections and it shows a trough of 10nmol/l ~ 300 ng/dl and a peak of 32nmol/l ~900ng/dl. Find out how to do peak-and-trough analysis. Background: A variety of preparations for testosterone replacement therapy are currently available. Clinicians should be aware of this high variability in levels when deciding on dose adjustment.Source of Funding: None, Bruno Nascimento Graduated in Medicine, Surgery and Urology at University of Sao Paulo, SP, Brazil; Member of the Sexual Medicine Group, Division of Urology, University of Sao Paulo Medical School, SP, Brazil; Recently finished a fellowship in Sexual Medicine and Andrology with John P. Mulhall at Memorial Sloan Kettering Cancer Center, NY, USA, MP67-04 - Impact of camera deviation on curvature assessments using goniometer and 2D photographies, MP67-09 - The Impact Of Intralesional Xiaflex On Psychosocial Outcomes in Men with Peyronie’s Disease (PD), MP85-14 - Variance In Peak And Trough Testosterone Levels In Men Using Intramuscular Testosterone. 3. All Rights Are Reserved. © Copyright 2019. In addition to that, 25% of patients had a maximum Tp change greater than 50% and maximum Tt change greater than 35%. For them the definition is total testosterone < 450 ng/dl.l. If you have any medical conditions, do your homework and discuss with your doctor. It is greatly helping their sex life, their relationships with women and their relationships at work. Learn More. The solid majority of their men just love HRT with this kind of protocol and wouldn’t have it any other way. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety. They dose with Arimidex if necessary to bring estradiol (E2) between 20 and 30 pg/ml. I assume dropping from 45 to 30 based on the link by testosterone23. Teens between the ages of 14 and 15 years should have between 8 to 53 ng/dL of testosterone in their blood, while 16 to 19-year-olds average 200 to 970 ng/dL. Blood tests can help to determine the level of testosterone in your blood. Here are a few examples: 1. The day after my shot I feel kind of crappy because E is higher than just before my next shot. This graph clearly demonstrates the ‘peak and trough’ that is often described by patients on such wide injection intervals. Testosterone reads are done at the trough, i.e.