physician global assessment sle

Franklyn K Conclusion: Data regarding divergent validity are lacking for the PGA. Global Respiratory Devices Market Size, Growth, Source Analysis, Top , Chan KL This scoring modality was used for the SRI [3]. , Engel SM Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. , Fang H In 89 studies [2, 3, 913, 21102] the PGA was used to measure disease activity as a whole, therefore satisfying the content validity criteria. Systemic Lupus Erythematosus and Lupus Nephritis - Epidemiology Oxford Textbook of Neuropsychiatry - 2020 | PDF | Psychiatry et al. Copay AG The responsiveness of the PGA is the ability to detect worthwhile variations in disease activity over time, measuring worsening or improvements in SLE disease status. This is a top barrier, both for treat-to-target management of SLE patients in clinical practice, as well as in clinical trials for new SLE treatments. Patient-Reported Outcomes in Systemic Lupus Erythematosus. The last MEDLINE search was performed on 1 July 2019. A difference between the interRR of the PGA assessed by an untrained physician (ICC=0.50.63) or a trained investigator (ICC=0.790.81) was found [36]. The Physician Global Assessment (PGA) is an important tool for assessing disease activity in lupus. , Mikolaitis-Preuss RA Responsiveness. The Physician's Global Assessment (PhGA) is a number without unit. et al. Please check for further notifications by email. In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. Content validity was reported in 89 studies. The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . CareerBuilder TIP. government site. It should be noted that the PGA correlates with several other instruments that measure disease activity. , Giannakou I Observed and articulated management issues and responses. , Sjwall C Mokkink LB Elisabetta Chessa, Matteo Piga, Alberto Floris, Herv Devilliers, Alberto Cauli, Laurent Arnaud, Use of Physician Global Assessment in systemic lupus erythematosus: a systematic review of its psychometric properties, Rheumatology, Volume 59, Issue 12, December 2020, Pages 36223632, https://doi.org/10.1093/rheumatology/keaa383. Reviews and case series with fewer than five patients were excluded. , Costenbader K 2014 Sep-Oct;10(5):309-20. doi: 10.1016/j.reuma.2014.01.012. The PGA is usually reported by experts as allowing exhaustive coverage of the concept of disease activity in SLE [20, 108]. Physician global assessments for disease activity in rheumatoid arthritis are all over the map!. [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. Tel: 03 88 12 84 74; Fax: 03 88 12 82 90; E-mail: Measuring disease activity in adults with systemic lupus erythematosus: the challenges of administrative burden and responsiveness to patient concerns in clinical research, Patterns of disease activity in systemic lupus erythematosus, Novel evidence-based systemic lupus erythematosus responder index, Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus, Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus, Treatment target in newly diagnosed systemic lupus erythematosus, 10 most important contemporary challenges in the management of SLE, Measurement of systemic lupus erythematosus activity in clinical research, Definition, incidence, and clinical description of flare in systemic lupus erythematosus. Vashisht P allergy hx phenothiazines, cns depressants and stimulants withheld 48 hours prior. , Rairie JE Patient global assessment in measuring disease activity in rheumatoid Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). et al. and transmitted securely. COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. , Gladman DD. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. The last EULAR/ACR recommendations recommended use of the PGA in the routine monitoring of SLE [16]. Please enable it to take advantage of the complete set of features! , Ogale S Ensure second line of defense Derivatives RWA reviews are performed consistently and . In one open-label study [43], the decrease in PGA score was considered the primary endpoint. However, it was used as a single outcome measure only in two studies [49, 100], while in the majority the PGA was scored together with another instrument (typically the SLEDAI) [2, 9, 11, 12, 21, 24, 30, 32, 34, 3740, 44, 45, 48, 49, 55, 58, 59, 61, 63, 64, 66, 67, 74, 75, 80, 82, 86, 8995, 103]. Mina R Criterion validity. , Magder L A multi-item Physician Global Assessment scale to assess psoriasis MD globals may vary based on their age, gender, practice setting and experience (number of patients seen per year and years in practice). PDF Use of Physician Global Assessment (PGA) in Systemic lupus - medRxiv The content can vary and relates either to global health (e . Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. , Terwee CB , Brunetta P Before , Karp DR Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. Patient and Physician Global Assessments of Disease Status in Systemic et al. 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. The interrater reliability (interRR) of the PGA is the ability to provide consistent scores in a stable population between two or more physicians who evaluate the disease activity of the same patient. , Bresee C , Tugwell P The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. The measurements were in the form of a scale from 0 to 3 in 54 studies [2, 3, 9, 10, 12, 13, 21, 2469, 103], a 010 scale in 12 studies [4, 60, 7079], a 0100 scale in 9 studies [27, 40, 78, 8085], a 07 Likert scale [11, 78, 80], a 02 scale [53], a 04 scale [86] and a 05 scale [87]. et al. , Ding HH , Hochberg M. Wallace DJ , Holland M (Open Access) Development and assessment of a computerized index of The visual analog scale (VAS)-based assessments, SELENA SLE Disease Activity Index (SLEDAI) Physician's Global Assessment (SSPGA) and Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL), can be used to assess common trial end points for systemic lupus erythematosus (SLE), according to study results published in Lupus Science & Medicine. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. In the last 30years, more than a dozen scores have been derived to assess disease activity in SLE, but not all of these have proven to be valid and reliable tools. , Gladman DD The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. Visual Analog Scale Assessments Can Reliably Assess Disease Severity in SLE The Validity of Patient and Physician Global Disease Activity , Dietzmann K European League Against Rheumatism. Objective: Barr et al. Frontiers | Cutaneous lupus erythematosus disease assessment The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. Barr SG Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: A systematic literature review. Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . , Garabajiu M , Engleman EG 04 Measuring SLE disease activity in 2020: perspectives from clinical The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinicians judgement of overall SLE disease activity. Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. , Magder LS Construct validity is shown by the good correlation observed with the SLEDAI, BILAG, SLAM, LAI and ECLAM [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. Treatment of lupus nephritis: consensus, evidence and perspectives The Handheld Dermatoscope as a Nail-Fold Capillaroscopic Instrument - JAMA , Gomez A , Urowitz MB Touma Z et al. , Devilliers H It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. According to the authors, this difference was probably due to the greater familiarity of the physicians with the BILAG-2004 index. , James JA , Lau CS Genetic linkage has related dysfunction of . et al. The .gov means its official. Assessing disease activity in rheumatic diseases such as systemic lupus erythematosus (SLE) is vital for effective treatment. RMD Open 2018;4:e000578. How does one assess and monitor patients with systemic lupus National Library of Medicine Supervise the development of junior medical affairs staff . Physician Global Assessment International - ScienceDirect Over the years, PGA-IGA scales were modified for the purpose of clinical settings and thus present a diversity in the number of response options (4 to 10 points), the response options label and the . , Khamashta MA Derivatives RWA Production Controller (SA-CCR/SLE) doi: 10.1136/rmdopen-2022-002395. , Kostopoulou M The term Physician Global Assessment (PGA) was coined in 1991 by Petri et al. Physician's Global Assessment in Psoriatic Arthritis: A Multicenter , McGwin G The search strategy for SSc-related publications identified 75 citations . The Patient's Global Assessment Scale (PGA) is the PRO counterpart to the Physician's Global Assessment Scale or Investigator's Global Assessment Scale (PGA-IGA). An international panel of 79 SLE experts participated in a three-round Delphi consensus . , Roberts WN At a glance: Common scores used in rheumatology SLE2ACR1997SLICC2012. , Vogel-Claussen J Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, Instrument selection using the OMERACT filter 2.1: the OMERACT methodology, The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes, Health measurement scales: a practical guide to their development and use, A decrease in complement is associated with increased renal and hematologic activity in patients with systemic lupus erythematosus, Efficacy and safety of methotrexate in articular and cutaneous manifestations of systemic lupus erythematosus, Performance of SLEDAI-2K to detect a clinically meaningful change in SLE disease activity: a 36-month prospective cohort study of 334 patients, Disease activity patterns over time in patients with SLE: analysis of the Hopkins Lupus Cohort, Comparison of the systemic lupus erythematosus activity questionnaire and the systemic lupus erythematosus disease activity index in a black Barbadian population, A pilot study to determine the optimal timing of the Physician Global Assessment (PGA) in patients with systemic lupus erythematosus, Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments, Derivation and validation of the SLE Disease Activity Score (SLE-DAS): a new SLE continuous measure with high sensitivity for changes in disease activity, Clinical SLEDAI-2K zero may be a pragmatic outcome measure in SLE studies, Erythrocyte-bound C4d in combination with complement and autoantibody status for the monitoring of SLE, Validation of SIMPLE index for lupus disease activity, Performance characteristics of different anti-double-stranded DNA antibody assays in the monitoring of systemic lupus erythematosus, Psychometric properties of MDHAQ/RAPID3 in patients with systemic lupus erythematosus, Therapeutic adherence in patients with systemic lupus erythematosus: a cross-sectional study, Sensitivity analyses of four systemic lupus erythematosus disease activity indices in predicting the treatment changes in consecutive visits: a longitudinal study, Comparison of the lupus foundation of America-rapid evaluation of activity in lupus to more complex disease activity instruments as evaluated by clinical investigators or real-world clinicians, Lupus low disease activity state is associated with a decrease in damage progression in Caucasian patients with SLE, but overlaps with remission, Impact of disease activity on health-related quality of life in systemic lupus erythematosusa cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS), Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study, Smoking and pre-existing organ damage reduce the efficacy of belimumab in systemic lupus erythematosus, Cross-cultural validation of Lupus Impact Tracker in five European clinical practice settings, Failure of a systemic lupus erythematosus response index developed from clinical trial data: lessons examined and learned, Belimumab for the treatment of recalcitrant cutaneous lupus, Progression of noncalcified and calcified coronary plaque by CT angiography in SLE, Impact of heart rate variability, a marker for cardiac health, on lupus disease activity, The lupus impact tracker is responsive to changes in clinical activity measured by the systemic lupus erythematosus responder index, Validation of the Lupus Impact Tracker in an Australian patient cohort, Axl, ferritin, IGFBP2 and TNFR2 as biomarkers in systemic lupus erythematosus, Lupus anticoagulant, disease activity and low complement in the first trimester are predictive of pregnancy loss, Lupus Impact Tracker is responsive to physician and patient assessed changes in systemic lupus erythematosus, Predictors of pregnancy outcomes in patients with lupus: a cohort study, Clinical, laboratory and health-related quality of life correlates of Systemic Lupus Erythematosus Responder Index response: a post hoc analysis of the phase 3 belimumab trials, Validation of the LupusPRO in Chinese patients from Hong Kong with systemic lupus erythematosus, The Swiss Systemic lupus erythematosus Cohort Study (SSCS)cross-sectional analysis of clinical characteristics and treatments across different medical disciplines in Switzerland, How should lupus flares be measured? . , Mina R A total of 91 articles were included in the study (Fig. Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. The patients were diagnosed as having the following disorders: scleroderma (n = 27), dermatomyositis (n = 11), systemic lupus erythematosus (SLE) (n = 22), MCTD (n = 8), and RP without evidence of underlying CTD (n = 38). , Fortin PR Methods PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. , Adamichou C They participate in physiologic and inflammatory cascades and have become a major focus of research, yielding novel therapies for immune-mediated inflammatory diseases (IMID). Physician global assessments for disease activity in rheumatoid arthritis are all over the map! Associations between physicians' global assessment of disease activity , Kiani AN Construct validity. Parodis I Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. , Socher SA The correlation with the SLEDAI was determined in 12 studies (Fig. Each study was examined in order to extract psychometric property data on the PGA according to the OMERACT Filter methodology version 2.1 [18]. Schlencker A, Messer L, Ardizzone M, Blaison G, Hinschberger O, Dahan E, Sordet C, Walther J, Dory A, Gonzalez M, Kleinlogel S, Bramont-Nachman A, Barrand L, Payen-Revol I, Sibilia J, Martin T, Arnaud L. Lupus Sci Med. , Petri MA Ann Rheum Dis 2 Isenberg DA, Allen E, Farewell V, et al. , Arbab-Zadeh A et al. , Sadovici-Bobeica V physician global assessment (pga) - Assesschild Touma Z Your recommendations as to what might or should be done in relation to various issues observed. , Urowitz MB Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients' age. , Saad-Magalhes C Systemic Lupus Erythematosus (SLE) Treatment & Management - Medscape Cloud, mobility, security, and more. Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. 2022 Jan 11;11(2):340. doi: 10.3390/jcm11020340. Disclosure statement: L.A. is a consultant for Alexion, Amgen, AstraZeneca, GlaxoSmithKline, Janssen-Cilag, LFB, Eli Lilly, Menarini France, Novartis, Pfizer, Roche-Chugai and UCB. Physician global assessment in systemic lupus erythematosus: can we What Does It Mean to Be a British Isles Lupus Assessment Group-Based The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Nehring J , Pilkington C Changes in the PGA correlated with changes of other disease activity indices (SLEDAI, SLAM, LAI, patient global assessment), laboratory exams (ESR), patient-reported outcomes (Lupus Impact Tracker) [23, 50, 58, 77, 78, 81, 83] and response to treatment [4]. et al. A PGA 2 correlated with a risk of pregnancy loss (29% vs 8%, P=0.005) [49]. Management of systemic lupus erythematosus (SLE) often depends on disease severity and disease manifestations, [] although hydroxychloroquine has a central role for long-term treatment in all SLE patients. Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. 10- Medical- Surgical- Nursing- Intensive- Review Clinical Trial on Systemic Lupus Erythematosus (SLE): Blood sample Currently no agreement has been reached on which scale should be used: a pointed scale with anchored values (0, 1, 2, 3) or a centimetric scale with all values between 0.0 and 3.0. , Chizzolini C Merrill JT Sullivan KE Notorious to increase IOP and cause severe PAIN and headache; Diagnostics: - History - Tonometry examinations - measures IOP QUESTION A client states that the physician has told her that her intraocular was 14. et al. Moreover, there is uncertainty as to whether the best timing of assessment is prior to or after reviewing laboratory exams [26]. Compared with nonresponders, BICLA responders had greater improvements in global and organ-specific disease activity (Physician's Global Assessment, SLE Disease Activity Index 2000, Cutaneous Lupus Erythematosus Disease Area and Severity Index Activity, and joint counts; all nominal P < 0.001). Disclaimer. [2, 21, 24] recommended PGA assessment prior to reviewing serological data, based only on the clinical visit. Physician global assessments for disease activity in rheumatoid , Ibanez D Retrieved papers were selected with no limitation on the year of publication, language or patients age. , Goldsmith CH PGA0.3. The assessment of disease activity in SLE is particularly challenging. , Burlingame RW physician global assessment Recently Published Documents. may be asked to hyperventilate 3-4 min and watch a bright flashing light. [PDF] Use of Physician Global Assessment in systemic lupus Using the Physician Global Assessment in a clinical setting to - PubMed , Subach RB , Liberati A Systemic lupus erythematosus (SLE), is the most common type of lupus. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index. Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. Content validity. Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76). An official website of the United States government. Vil LM No study has evaluated the correlation of PGA with damage measures. Ragai Kiriakos, MD, MSc - Clinical Trials Physician - LinkedIn This button displays the currently selected search type. disease activity in SLE, with the Physician Global Assessment (PGA) being the only one included in the updated EULAR recommendations for the management of SLE.11. Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). et al. Construct validity was demonstrated by a good correlation (r0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). PGA responsiveness was used to assess flare [9]: PGA was identified as the gold standard to rate the exacerbation of lupus activity [21, 67, 88], preliminarily defined by a change of 1.0 on a 03 VAS since the last visit. , Klein-Gitelman MS FitzGerald and Grossman [10] found a good interRR in a retrospective assessment of the PGA (=0.79). Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. , Voskuyl A An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were . Fatigue is independently associated with disease activity assessed using the Physician Global Assessment but not the SLEDAI in patients with systemic lupus erythematosus. et al. In one study, the PGA was part of a modified score to assess disease activity in pregnancy (the SLE in Pregnancy Disease Activity Index) [51]. Ruiz-Irastorza G , Socher SA antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). , Petri MA , Bertsias G et al. , Buyon J Published by Oxford University Press on behalf of the British Society for Rheumatology. Liang et al. Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index, Effect of raloxifene on disease activity and vascular biomarkers in patients with systemic lupus erythematosus: subgroup analysis of a double-blind randomized controlled trial, Omega-3 in SLE: a double-blind, placebo-controlled randomized clinical trial of endothelial dysfunction and disease activity in systemic lupus erythematosus, Erythrocyte sedimentation rate is a predictor of renal and overall SLE disease activity, Characterization of clinical photosensitivity in cutaneous lupus erythematosus, Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus, Depressive symptoms and associated factors in systemic lupus erythematosus, Validation of the Portuguese simple measure of impact of lupus erythematosus in youngsters (SMILEY) in Brazil, Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers, Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus, An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA, Noncalcified coronary plaque in systemic lupus erythematosus, Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus, Validity and reliability of lupus activity measures in the routine clinic setting, Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting.

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