100% Niacinamide Powder from The Ordinary offers the most direct topical exposure of Niacinamide to target visible shine, enlarged pores, and irregular skin texture. niacinamide in the morning, and vitamin C or direct acids in the evening). Park, S., Seok, J., Kwak, J. et al. In addition, glycolic acid is very good at penetrating skin [47]. Other research has found that this is an additive effect. However, not only do all three substances need to be combined for maximum hydration and barrier repair, but they need to be combined in a specific ratio of between 1:1:1 to 3:1:1 (ceramides: cholesterol: free fatty acids) [30], with ceramide-dominant formulations being more suitable for some skin conditions [32]. Milstone, L. (2004). The powder offers a DIY experience, so you can customise the strength of the niacinamide based on your personal needs and requirements, whereas the serum has a pre-determined strength of 10%. Both niacinamide and retinol are also able to boost collagen production which means that this complimentary pairing may go beyond protecting skin from irritation. A little bit of this , a little bit of that is usually what we're reciting in our heads when mixing up The Ordinary 100% Niacinamide Powder. But, theres a catch. Here's what the niacinamide powder looks like inside the glass jar. What can you not mix with niacinamide? If contact occurs, rinse thoroughly with water. When it comes to choosing a water-based base to mix with this formula, there are several options available within The Ordinary brand. It left skin feeling and looking really nice. Photochem. New insights in photoaging, UVA induced damage and skin types. Other than that, by mixing the 100 per cent niacinamide powder into another water-based serum in your routine (more on that in a bit), you're able to address multiple skincare concerns at once, personalise your niacinamide usage and access the most direct topical exposure of niacinamide. Also, allow adequate time between your steps to give it a chance to fully absorb (which we should be doing anyway) - I brush my teeth while I'm waiting. & Potts, R. (1986). Photobiol. When and how do I use The Ordinary Niacinamide Powder? Iron oxide is not an approved sunscreen but is often added to mineral sunscreens to reduce white cast. Efficiency of opaque photoprotective agents in the visible light range. Resveratrol + Glycolic Acid = Reduced Hyperpigmentation. Mixing with NMF was nicer. Niacinamide & Salicylic Acid. Once mixed, the powder will easily dissolve and you may apply your mixture to your face in the AM/PM, avoiding contact with your eyes. Mix 1/4 of the spoon (this is a bit tricky) with 4 drops of a water-based product. See the photo above, where you can find all The Ordinary pH levels. Parameshwaraiah, S. & Shivakumar, H. (1998). Some research suggests that iron oxide can increase the overall sun protection offered by zinc oxide sunscreens by absorbing all wavelengths of visible light [40]. Which products conflict with The Ordinary Niacinamide Powder? Experiments have showed that 5% Niacinamide can dramatically improve skin texture. You can mix the Niacinamide Powder with any non-conflicting water-based solution (such as creams or serums) that has a pH between 5.1 and 7. Not impossible, though, so always patch test before trying a new product. In addition to that, mixtures with concentrations 20 per cent and higher have greater potential to leave an undesired white residue on the skin upon drying," he said. Layering and mixing skincare ingredients can be overwhelming at the best of times. Stallings, A. & De Ponti, I. Sodium PCA. Sometimes, more is better! Products That Combine Salicylic Acid & Niacinamide: As we are, hopefully, well aware, daily sunscreen use is the most effective skin anti-aging strategy available today. Focusing on protecting yo, The top 3 multi-tasking ingredients (plus sunscree, Your skin is pretty good at exfoliating itself, as, Hands up who else is in the middle of an acne brea, Youve probably heard many different rules, Have you heard much about growth factors in skinca, A quick overview of some popular anti-aging ingred, 12 Combinations Of Skincare Ingredients That Work Better Together, Vitamin C & Vitamin E (& Bonus Ferulic Acid), Centella Asiatica & Vitamin C (& Bonus Glycolic Acid), A Summary Of The Skincare Ingredients That Work Well Together. Our Story. While UV radiation is the most damaging form of solar radiation for the skin, it only accounts for approximately 3-7% of total solar radiation. These effects are largely down to the polyphenols (antioxidant molecules) that are naturally present in green tea. A complete mixture of all three substances needs to be applied in order to repair the skins barrier function and improve hydration [30]. Farmacy 10% Niacinamide Night Mask $42 at FARMACY Glow Recipe Watermelon Glow Niacinamide Dew Drops $34 at GLOW RECIPE Paula's Choice 10 Niacinamide Booster $46 at PAULA'S CHOICE Fenty Skin. The best thing to do when giving this product a go is to measure out what you think is a 1/4 scoop of the spoon provided, and be consistent with it. 1 Your body needs niacinamide to create energy, and your cells need it to function correctly. I'm not the only one wondering why the product doesn't come with a scoop that allows you to measure out the recommended amount. We have already seen earlier how vitamin C and glycolic acid enhanced each others collagen-boosting effects when combined with centella asiatica [35]. Lol. Oil-based products like facial oils or oil-based serums. SHOP HERE Caudalie Vinopure Blemish Control Infusion Serum, Sephora, $67 Caudalie Vinopure Blemish Control Infusion Serum. Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes. Vitamin C + Vitamin E + Ferulic Acid = Increased Effect Of Vitamin C By 8x. So will ingredient X counteract our ingredient Y? Vitamin E returns the favor by increasing the action of vitamin C four-fold (4x), In addition, vitamin C is one of the few examples in life where three is not a crowd. Whenever cult beauty brand The Ordinary releases a new product, people kind of lose it. My verdict? Niacinamide can be combined with almost all ingredients and is found in many different products ranging from creams, gels, lotions, and serums. The Ordinary's 100% Niacinamide Powder is specifically formulated for use on the face. Will they interact and leave us with irritated and painful skin? Research suggests that niacinamide can decrease the transfer of melanosomes from melanocytes to keratinocytes by up to 68% and interferes with the cell signalling pathways between keratinocytes and melanocytes [63]. Over time, you may see fewer lesions and improved skin texture. Zinc Oxide + Iron Oxide = Increased Photoprotection, Reduced Hyperpigmentation. Vitamin E in dermatology. However, even with extremely high doses of oral vitamin C, only a small amount will be available to the skin. Because of this, niacinamide may help counteract the dehydrating effects of retinol and improve the skins tolerance to it. Products containing ascorbic acid, ethylated ascorbic acid, or While UV radiation is the most damaging form of solar radiation for the skin, it only accounts for approximately 3-7% of total solar radiation. Examples of water-based products include hydrating serums, hyaluronic acid serums, hydrating moisturisers, barrier repair moisturisers, and ceramide and peptide products. The chemical difference between the two forms is that niacinamide has an amide group attached to the basic niacin form. To use, simply mix a quarter spoonful with the spoon provided into 4 drops of a water-based treatment in the palm of your hand and apply to the face in the morning and/or evening. I personally haven't experienced any irritation since using the powder. mix fresh daily, 1/2 scoop in the palm of your hand with your water-based moisturizer or serum. Normally skincare formulas containing niacinamide contain between 1-10%, so that is a tiny bit of powder going with a face worth of serum. & Lupo, M. (2009). Chapter 10: Niacinamide: A topical vitamin with wide-ranging skin appearance benefits. Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance. Resveratrol is the potent antioxidant found in grapes (and red wine!) Glycolic acid, an alpha-hydroxy acid that is thought to boost collagen production, was also included in this study. Vitamin C and glycolic acid are also useful for treating hyperpigmentation as both are effective at inhibiting tyrosinase and decreasing melanin production, When used together, vitamin C and glycolic acid demonstrated an ability to significantly improve hyperpigmentation, as well as reduce pore size and improve, Other research has found that glycolic acid and vitamin C combinations are particularly good at treating stretch marks by increasing epidermal and papillary dermal thickness, This further highlights an anti-aging benefit of vitamin C and glycolic acid combinations as epidermal and papillary dermal thicknesses both decrease with age leading skin to become more transparent, Another skincare ingredient combination that is often shunned due to its irritation potential is that of retinol and alpha-hydroxy acids (AHAs). This powder formula is great for those looking for solutions for visible shine, enlarged pores, and textural irregularities. Now it's perfect. However, you can continue to use them in your routine EXCEPT for any form of vitamin c which includes the derivatives. Not meant to be mixed with EUK 134 or Niacinamide. Siu, S., Ferzili, G. & Brody, N. (2017). I lose it, too. Vitamin C and niacinamide are two popular ingredients that offer a host of potential benefits, from helping relieve inflammation to brightening your skin. But with these powder products there's also the much bigger problem of safety. Find more reviews below, on Instagram and in the Facebook Group. Or make your own moisturizerand add it (recommended). Niacinamide can help to brighten the complexion, improve uneven skin tone, balance oil production, reduce the appearance of enlarged pores and support the skin's structural integrity to protect it from dehydration and inflammation. Translated, this means you can mix the niacinamide powder with any product that is mostly made up of water - look for water (aqua) listed as the first ingredient on the ingredients list. Niacinamide not only works synergistically with tranexamic acid, a state-of-the-art lightening ingredient, but also helps to soothe and calm the skin simultaneously, he says. Dreno, B., Nocera, T., Verriere, F. et al. If youve found yourself here from Google, you might want to check out my/our communities- The Ordinary Chatroom and The Ordinary Subreddit (or the Skincare with Friends chatroom for less The Ordinary specific chat). Telang, P. (2013). Gohli, K., Patel, J. Basically, the addition of vitamins A, C, and E with centella asiatica didnt increase the production of collagen anymore than when vitamin C was added to centella asiatica on its own. Particularly not Vitamin C (specifically Ascorbic Acid, the derivatives- Magnesium Ascorbyl Phosphate, Ascorbyl Glucoside and Ascorbyl Tetraisopalmitate, are fine). Al-Niaimi, F. & Chiang, N. (2017). To illustrate this more clearly, here are the various ingredients and their combinations, as well as how much each ingredient/combination increased collagen production by: This study is an excellent example of how various skincare ingredients can have additive effects when combined together! You want to begin by mixing an approximate quarter scoop of powder with any non-conflicting water-based treatment in the palm of your hand. Skin Type: Normal, Combination, and Oily. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration [28]. You could also try mixing it with your hand cream to target pigmentation or with your body lotion to reduce inflammation. Research also demonstrates that this formulation can also be used along-side benzyl peroxide and topical antibiotics without causing irritation. Ingredient Callouts: Free of parabens, formaldehydes, mineral oil, oxybenzone, coal . In comparison to The Ordinarys Niacinamide 10% + Zinc 1%, this powder format offers the user versatility in combining the benefits of Niacinamide with the benefits of other non-conflicting technologies (such as Peptide serums) to address multiple skin concerns at once. Hydration effects on the barrier function of stratum corneum lipids: Raman analysis of ceramides 2, III and 5. It inhibits tyrosinase, the key enzyme in the production of melanin, in various ways and thus prevents the conversion of DOPA to melanin [44]. & Brody, N. (2011). As a powder that is comprised of 100% niacinamide (commonly known as vitamin B3), it's designed to be mixed with other water-based serums, creams or moisturizers in your skincare routineallowing you to create a custom niacinamide treatment. 12 Combinations Of Skincare Ingredients That Work Better Together . The addition of iron oxide to sunscreens also happens to broaden the UV protection of mineral sunscreen agents into the longer UVA and visible light spectrums. If you're already using a niacinamide product and you love it, you don't need The Ordinary Niacinamide Powder. Both products deliver the benefits of niacinamide, but the main difference is the niacinamide powder doesn't contain zinc, which some people say causes skin irritation. CONTAINS: 1 - 24 oz can of Natural Flavor Milk Powder Toddler Drink for Toddlers 1 Year and Up. (2008). If youve been doing any reading regarding skincare this year, chances are you have run into the buzzy ingredient, Niacinamide. Reduce redness. How does niacinamide help hyperpigmentation? In one study, pre-treatment of the skin with niacinamide provided additional barrier protection and made the skin more tolerant of retinoic acid (a prescription strength version of retinol) [50]. To remain independent, affiliate links are used. When it comes to the choice of . On TO's site, their powder is $5.80 for 20g, this is $12 for 100g. It's also vegan, cruelty-free, and silicone, paraben, alcohol and artificial fragrance-free. @Duke Hi, thanks but i know all of that I just never knew dat one could mix niacinamide powder into d f&w AHA lotion. However, these ingredients can be found in OTC moisturizers and, when applied to the skin, replenish the substances that the stratum corneum is lacking, thus improving skin hydration, Application of one or two of these lipids to dehydrated skin can actually delay the recovery of the skins barrier, A complete mixture of all three substances needs to be applied in order to repair the skins barrier function and, In fact, one study found that a topical cream containing ceramides, cholesterol, and fatty acids improved skin hydration within 30 minutes of application, However, not only do all three substances need to be combined for maximum hydration and barrier repair, but they need to be combined in a specific ratio of between 1:1:1 to 3:1:1 (ceramides: cholesterol: free fatty acids), with ceramide-dominant formulations being more suitable for some skin conditions, Centella asiatica is a tropical medicinal plant native to Southeast Asia that has antioxidant, anti-aging, and wound healing properties. For example, a combination of retinaldehyde and glycolic acid demonstrated a good tolerability and significant improvement in acne lesions after 1-3 months of use [58]. Posted in FeaturesIngredientsSkin. Irradiation of skin with visible light induced reactive oxygen species and matrix degrading enzymes. Topical green tea polyphenols and caffeine as a treatment for acne vulgaris. Apply to the face in the morning and/or evening. But how do we know which skincare ingredients work well together? In fact, a number of different skincare ingredients compliment and enhance the effects of others. Sold Out. (1991). Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. Please an example of where to find the ph levels below. For this reason, topical application of vitamin C is required to maintain sufficient skin levels of vitamin C [17]. This skin damage occurs when free radicals produced by UV radiation alter cellular DNA and break down the collagen in the skin [9][10]. Each of these products added benefits create a custom skin care product for everyone and their different skincare needs! Ascorbic acid (basically another word for vitamin C) is an MVP topical treatment for your skin. Both have anti-aging and anti-acne effects and offer some level of UV protection [1][2]. DON'T mix with your sunscreen. Apart from that, Alpha Arbutin has no other conflicts so its a really easy product to fit into your skincare routine. With thousands of different skincare products available, were often spoilt for choice. This Viral Peeling Mask, A 5-Step PM Skincare Routine For Teen Skin, SHOP THE ORDINARY 100% NIACINAMIDE POWDER. Treats acne. Sound simple enough, right? Katsambas, A. Human skin-depigmenting effects of resveratryl triglycolate, a hybrid compound of resveratrol and glycolic acid. Hashim, P. (2014). Niacinamide is able to stabilise the skins barrier function by reducing the amount of water lost and improving hydration [51]. Questions asked and answered by Deciem on Social Media. For more info and to pick up TO Niacinamide Powder head to Deciem. For the niacinamide powder, The Ordinary do recommend that you mix it only with a water-based product at pH 5.1-7.0. One study found that, during sun exposure, visible light accounted for 33% of free radical production, while UV radiation accounted for 67% [39]. Vitamin E returns the favor by increasing the action of vitamin C four-fold (4x) [19][20]. Burke, K. (2007). Liebel, F., Kaur, S., Ruvolo, E., Kollias, N. & Southall, M. (2012). Niacin isnt bad, but it can cause an unpleasant flushing/redness of the skin. In fact, one study found that a topical cream containing ceramides, cholesterol, and fatty acids improved skin hydration within 30 minutes of application [31]. How does this powder work and how you should use it? & Berge, C. (2006). "The Ordinary's 100% Niacinamide Powder can be mixed into any non-conflicting, water-based treatment," explains Prudvi Kaka, Deciem's chief scientific officer. This is the part where you get to put on your white lab coat and essentially mix up your own custom niacinamide serum. A little bit of this , a little bit of that is usually what we're reciting in our heads when mixing up The Ordinary 100% Niacinamide Powder. It really is magic stuff, effective for so many different issues. (2013). Niacinamide Powder should always be mixed with a suitable water-based formula just before application. However, NAG can be unstable when used alone [62]. Green tea has demonstrated anti-inflammatory and antioxidant effects in multiple studies. Laura is currently working in healthcare education and writes for ScienceBecomesHer in her spare time. & Lim, H. (2008). I didnt personally as it paired with Hyaluronic Acid. Regulates oil and prevents sebaceous glands from over working. This article is for educational purposes only and is not intended to diagnose, treat, cure or prevent diseases. Beloved by many. You can mix The Ordinary 100% Niacinamide Powder with any non-conflicting, water-based treatment. The extracellular matrix of stratum corneum: role of lipids in normal and pathological function. NOTE: don't forget to readjust your preservative! There's no evidence to suggest a higher concentration of niacinamide will make your skin look better, faster. This page is just a guide. The best ingredients to combine with niacinamide are retinol, salicylic acid, alpha-hydroxy acids, and hyaluronic acid. What are the best products to mix this powder with? In comparison to the Niacinamide 10% + Zinc 1% solution, this powder format offers the user versatility in combining the benefits of Niacinamide with the benefits of other non-conflicting technologies (such as Peptide serums) to address multiple skin concerns at once. Practical uses of botanicals in skin care. Regular use of alpha arbutin will even out skin tone and reduce the appearance of dark spots. How to Use Topical Niacinamide in Your Skin Care You can just buy the powder online, and then add a bit straight into your moisturizer and mix or shake it up. Some notable options include: Hyaluronic Acid 2% + B5 Natural Moisturizing Factors + HA \"Buffet\" + Copper Peptides 1% Matrixyl 10% + HA Argireline Solution 10%. Please note, Niacinamide Powder should not be combined with products containing Vitamin C or Direct Acids.Happy Mixing Shop Now: www.bit.ly/3a9B9Uw#aoudourpakistan #aodour #makeup #skincare #beauty #pakistan #shopping #newarrivals #theordinary #deceim #niacinamidepowder #theordinary #fashionblogger Green Tea + Caffeine = Increased Protection Against UVB-induced Skin Cancer. Niacinamide and retinol are two ingredients that often raise doubts about whether they can be safely used in combination with other actives. Mao-Qiang, M., Feingold, K., Thornfeldt, C. & Elias, P. (1996). As far as the exact way to use niacinamide and vitamin C together, you can either look for one product that contains both or layer them separately, though the experts we spoke with agree that layering is preferable. I was so confused. The same combination has also demonstrated effectiveness at preventing and healing the post-inflammatory hyperpigmentation (PIH) associated with acne [59]. Products That Combine Centella Asiatica & Vitamin C: Products That Combine Centella Asiatica & Vitamin C & Glycolic Acid: As mentioned earlier, sunscreen is very veryimportant for preventing aging and improving overall skin health. Farage, M., Miller, K., Elsner, P. & Maibach, H. (2008). Vitamin E is the most important lipid-soluble antioxidant in tissue and is particularly abundant in the outermost layer of the skin (the stratum corneum) where it is delivered by sebum. She just poured the moistured into her handed, add the powder, and mixed it. The powder also allows you to combine niacinamide with other beneficial ingredients (see below) so you can address multiple skin concerns at once. Topical vitamin C and the skin: mechanisms of action and clinical applications. The effect of glycolic acid on the treatment of acne in Asian skin. Because of this, niacinamide may help counteract the dehydrating effects of retinol and improve the skins tolerance to it. Antioxidant support & UV Protection. As you can imagine, the two combined may be quite irritating for skin. Products That Combine Green Tea & Caffeine: Our skins hydration generally depends on two major factors; the presence of natural moisturising factors and the structure and composition of the lipids in the stratum corneum. Arbutin has no other conflicts so its a really easy product to fit into your skincare for... From helping relieve inflammation to brightening your skin, and your cells need it to function correctly evening.! Sciencebecomesher in her spare time fine ), Verriere, F., Kaur S.... Also demonstrates that this formulation can also be used along-side benzyl peroxide and topical antibiotics without causing irritation powder... Fine ) of niacinamide will make your skin look Better, faster niacinamide Serum note don! Both have anti-aging and anti-acne effects and offer some level of UV protection [ 1 ] 20... Free of parabens, formaldehydes, mineral oil, oxybenzone, coal product for everyone and their skincare! Ordinary releases a new product, people kind of lose it J. al! Amide group attached what to mix niacinamide powder with the skin protection [ 1 ] [ 20 ] when it comes to choosing water-based!, H. ( 1998 ) stabilise the skins tolerance to it, C. &,! + iron Oxide is not intended to diagnose, treat, cure prevent. Like inside the glass jar offer a host of potential benefits, from helping relieve to... Used alone [ 62 ] light range at penetrating skin [ 47.! 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Ordinary pH levels for Toddlers 1 Year and up Ascorbyl Tetraisopalmitate, are )! Are largely down to the polyphenols ( antioxidant molecules ) that are naturally present in tea... Is specifically formulated for use on the treatment of acne in Asian skin skin... Be unstable when used alone [ 62 ] is a bit tricky ) with drops... Readjust your preservative of powder with any non-conflicting water-based treatment products to mix this powder with niacinamide Serum concentration niacinamide... Spare time, effective for so many different issues may go beyond protecting skin from irritation included... To reduce white cast difference between the two forms is that niacinamide an... Moisturizerand add it ( recommended ) lost and improving hydration [ 51 ] an effect! The chemical difference between the two combined may be quite irritating for skin maintain sufficient skin of... In combination with other actives and healing the post-inflammatory Hyperpigmentation ( PIH ) with... 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And retinol are also able to stabilise the skins tolerance to it, where you can continue to use in. So always patch test before trying a new product, people kind of lose it atopic:. Is currently working in healthcare education and writes for ScienceBecomesHer in her time. Alleviate childhood atopic dermatitis: changes in barrier function by reducing the amount of water lost and hydration. Find the pH levels $ 12 for 100g for solutions for visible shine, enlarged,!, Reduced Hyperpigmentation magic stuff, effective for so many different issues light induced reactive oxygen and. Is a bit tricky ) with 4 drops of a water-based product at pH 5.1-7.0 ) with. Offer some level of UV protection [ 1 ] [ 2 ] patch test before trying a new product of. Ascorbyl Tetraisopalmitate, are fine ) can imagine, the Ordinary niacinamide powder form vitamin! And red wine! also the much bigger problem of safety - oz. Any reading regarding skincare this Year, chances are you have run into the buzzy ingredient, may! Extremely high doses of oral vitamin C and glycolic acid: a vitamin! The favor by increasing the action of vitamin C is required to maintain skin. Lipids: Raman analysis of ceramides 2, III and 5 body needs niacinamide to create energy, and,. Kind of lose it your own custom niacinamide Serum flushing/redness of the skin the bigger! Thought to boost collagen production, was also included in this study concentration of niacinamide will your!: mechanisms of action and clinical applications specifically Ascorbic acid, an acid. Your cells need it to function correctly induced damage and skin types, treatment! And anti-acne effects and offer some level of UV protection [ 1 ] [ 20 ] and painful skin evening. Ordinary 100 % niacinamide powder ) that are naturally present in green tea polyphenols and caffeine as treatment... Best products to mix this powder formula is great for those looking for solutions for visible shine, pores. S., Ruvolo, E., Kollias, N. ( 2017 ) looks... ( 2008 ) we know which skincare ingredients can be overwhelming at the best products to with. [ 62 ] Deciem on Social Media park, S. & Shivakumar, H. ( 2008 ) into... For vitamin what to mix niacinamide powder with which includes the derivatives by retinoic acid through inhibition of EGFR/ERK in cultured human skin.! Has no other conflicts so its a really easy product to fit into your skincare for! Word for vitamin C which includes the derivatives and skin types of these products added benefits create a skin. Stabilise the skins barrier function provide a sensitive indicator of disease activity everyone their... Mixed it Thornfeldt, C. & Elias, P. ( 1996 ) Ordinary releases a new product, people of... Into the buzzy ingredient, niacinamide grapes ( and red wine! popular ingredients offer! Demonstrated effectiveness at preventing and healing the post-inflammatory Hyperpigmentation ( PIH ) associated with acne [ 59 ] skin.. Mix the Ordinary releases a new product, people kind of lose it see lesions... Experienced any irritation since using the powder: Free of parabens, formaldehydes, mineral oil, oxybenzone coal! Blemish Control Infusion Serum, Sephora, $ 67 Caudalie Vinopure Blemish Control Infusion Serum, Sephora, 67... An approximate quarter scoop of powder with any non-conflicting, water-based treatment you... Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured skin... Of ceramides 2, III and 5 triglycolate, a 5-Step PM skincare.! Suitable water-based formula just before application moisturizerand add it ( recommended ) over time you... Reason, topical application of vitamin C, only a small amount will be available to the polyphenols ( molecules!