Updated results from a large study suggest that the drug abemaciclib (Verzenio) may be a new treatment option for people with the most common type of breast cancer. UPDATE: On October 12, 2021, the Food and Drug Administration (FDA) approved abemaciclib (Verzenio) in combination with endocrine therapy (either an aromatase inhibitor or tamoxifen) following surgery to treat some people with HR-positive, HER2-negative breast cancer. In the past 30 days, Verzenio has had 117 airings and earned an airing rank of #1,861 with a spend ranking of #993 as compared to all other advertisers. Download the 2023 Super Bowl TV Ad Report from iSpot Today. Have questions about this ad or our catalog? Jesse, Natures Answer 25% Off Promo Code Commercial Sambucus Immune Products Mother Nature, Pringles Super Bowl Ad 2023 Meghan Trainor Teaser. In part, thats because in two other clinical trials involving a similar group of patients, adding the CDK4/6 inhibitor palbociclib to adjuvant hormone therapy failed to improve invasive disease-free survival. And most of the time the cancer is classified as HR positive and HER2 negative. Competition for Eucerin includes Proactiv, Olay, Gold Bond, Neutrogena (Skin Care), Cicatricure and the . Published March 11, 2020 Advertiser Verzenio Advertiser Profiles Facebook, Twitter Products Verzenio Tagline "Every Day Matters" Songs - Add Download the 2023 Super Bowl TV Ad Report from iSpot Today. Overall, side effects were more common in the abemaciclib group, leading more of these participants to skip doses of the drug or take lower doses. In some instances, patients will receive a short course of chemotherapy before surgery, also known as neoadjuvant therapy, to shrink the tumor and improve the chances that it can be completely removed. Give us your smile through contact form or comment box. But it was her volunteer work with a patient support organization that connected her to producers creating direct-to-consumer (DTC) advertising for Eli Lilly's drug Verzenio (abemaciclib). Casting a national pharma commercial for Verzenio. The majorefficacy outcome measurewas invasive disease-free survival (IDFS). Have questions about this ad or our catalog? I want to like this commercial because it stars Khrystine Haje, who is a cancer survivor, but the young girl playing the daughter or granddaughter looks scared of her, and it bothers me. Before posting or commenting, please check the rules in the sidebar. If FDAs approval of abemaciclib is expanded to include early-stage breast cancer, Dr. Korde said, oncologists will need to discuss the pros and cons of this treatment option with their patients. The commercial where a guy picks up his filthy wife and her friends from biking but won't unlock the door. Besides working for AT&T, the actress was also a regular in the Yahoo! Download the 2023 Super Bowl TV Ad Report from iSpot Today. IHOP Win Ant-Man and the Wasp: Quantumania Movie Ticket Commercial Teams Up With Marvel Studios, Watch Holidays Romeo and Juliet Song by Duke & Jones Louis Theroux Amazon Cyber Monday Commercial 2022, Proud Parent PrettyLitter TV Commercial Ad, PopCorners Breaking Bad Super Bowl Teaser Feat. NCI: Coronavirus: What People With Cancer Should Know. FDA also approved theKi-67IHCMIB-1 pharmDx (Dako Omnis) assay,submitted byAgilent, Inc.,as a companion diagnostic for selectingpatients for this indication. Nearly 90% of people diagnosed with breast cancer have early-stage disease. Once verified, the information you provide will be displayed on our site. Results from a clinical trial point to a possible new treatment choice for some women with the most common form of breast cancer. Mirror TV Spot, 'You're Not Alone' Song by Nvdes, Domino's TV Spot, 'Pizza Pit Stop' Featuring Denny Hamlin, This site uses cookies to provide you with a great user experience. Verzenio is used to treat a certain kind of metastatic breast cancer in certain situations. In October 2021, the FDA added a new approval for Verzenio (abemaciclib). Once verified, the information you provide will be displayed on our site. Your smiling is greater than everything. - Verzenio provides a new treatment option for women with HR+, HER2- advanced breast cancer - Verzenio is the only CDK4 & 6 inhibitor approved with a continuous dosing schedule INDIANAPOLIS, October 4, 2017 - Eli Lilly and Company (NYSE: LLY) announced that the U.S. Food and Drug Administration (FDA) has approved Verzenio (abemaciclib) in combination with fulvestrant for the treatment of . Verzenio is a medication that when taken as prescribed is intended to help treat those diagnosed with HR+ and HER2- metastatic breast cancer. Submissions should come only from actors, their parent/legal guardian or casting agency. Dr. Rastogi also presented results for the subgroup of patients with a high Ki-67 index score. Feel free to make a comment with smile. Download the 2023 Super Bowl TV Ad Report from iSpot Today. Khrystyne Kamil Haje ( / krstin h / Hozh; [1] born December 21, 1968) is an American actress. I don't think she's attractive or funny.And that bad Dennis Miller vocal affectation at the end makes me crazy. That raises the question of whether the improvement in invasive disease-free survival could disappear after the monarchE participants are followed for a longer time, said C. Kent Osborne, M.D., of the Dan L. Duncan Comprehensive Cancer Center at Baylor College of Medicine, during a press briefing. Participants treated with abemaciclib did have a higher risk of some side effects, including a very small number of women who experienced blood clots or inflammation in the lungs. Sign up to track 20 nationally aired TV ad campaigns for Eucerin. Published January 16, 2021 Advertiser Verzenio Advertiser Profiles Facebook Twitter Products Verzenio Tagline "Every Day Matters" Songs - Add About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features NFL Sunday Ticket Press Copyright . By using iSpot.tv, you accept our, Eucerin Advanced Repair TV Spot, 'Ceramidas y factores de humectacin naturales' [Spanish]. It is now also approved to treat people with HR+/HER2- EBC who are at high risk of their cancer coming back after surgery. While the Summer Olympics don't start until later this month, Eli Lilly and its Team USA athletes are already taking on health conditions in ads and videos for Lilly medic Discovery+ Onision In Real Life TV Commercial Ad. This review used theReal-Time Oncology Review(RTOR) pilot program,which streamlined data submission prior to the filing of the entire clinical application,andtheAssessment Aid, a voluntarysubmission from the applicant to facilitatetheFDAs assessment. INDIANAPOLIS, Oct. 13, 2021 /PRNewswire/ -- The U.S. Food and Drug Administration (FDA) has approved Eli Lilly and Company's (NYSE: LLY) Verzenio (abemaciclib), in combination with endocrine therapy (tamoxifen or an aromatase inhibitor), for the adjuvant treatment of adult patients with hormone receptor-positive (HR+), human epidermal growth Have questions about this ad or our catalog? Once verified, the information you provide will be displayed on our site. Results from one of those trials, called Penelope-B, also were presented at SABCS. The trial was funded by Eli Lilly, which manufactures abemaciclib. Submit ONCE per commercial, and allow 48 to 72 hours for your request to be processed. r/CommercialsIHate . Submissions should come only from actors, their parent/legal guardian or casting agency. Standard treatment includes surgery and radiation, followed by adjuvant treatment with hormone-blocking drugs (also called endocrine therapy) and, for many patients, chemotherapy. Nearly 17% of participants in the abemaciclib group stopped taking the drug because of side effects, compared with fewer than 1% of participants in the hormone therapyonly group. Inpatients with high risk of recurrence and Ki-67 Score 20%(N=2003), the trial demonstrated a statistically significant improvement in IDFS(HR 0.626; 95% CI: 0.488, 0.803; p=0.0042). One unanswered question is whether the treatment is actually preventing recurrences or just delaying them, she said. Mirror TV Spot, 'You're Not Alone' Song by Nvdes, This site uses cookies to provide you with a great user experience. Previously, Verzenio was used to treat advanced HR+/HER2- breast cancers. Shortness of breath. (See Table). Submit ONCE per commercial, and allow 48 to 72 hours for your request to be processed. But several factors are known to increase the risk, including whether the cancer has spread to several lymph nodes near the breast (in the armpit), having a large tumor in the breast, and having a higher grade cancer, meaning there are certain physical features of tumor tissue (under a microscope) that are indicative of more aggressive cancer. Those results show more than 86% of people treated with abemaciclib and endocrine therapy had not experienced a recurrence after 3 years compared with 79% of those treated with endocrine therapy alone. Check out our FAQ Page. Neulasta Onpro TV Spot, 'Support at Home', Opdivo TV Spot, 'A Chance to Live Longer', Keytruda TV Spot, 'It's TRU: Sharon's Story - Living Longer Is Possible', This site uses cookies to provide you with a great user experience. Download the 2023 Super Bowl TV Ad Report from iSpot Today. While oncologists who specialize in treating breast cancer largely agreed that the trial findings are promising, they also noted that its not yet clear if abemaciclib is ready for widespread use in patients with early-stage disease. The Belmont, California native took part in a commercial for the treatment, and was one of hundreds of patients the big pharma says it consulted before . However, several breast cancer experts noted that its not yet clear how abemaciclib would be used to treat early-stage breast cancer. But on the heels of Verzenio's strong showing in early HR+/HER2- breast cancerand Ibrance's missone influential analyst figures the Eli Lilly drug will quickly pick up steam. After the series ended in 1991, she continued acting in both television and films. Verzenio is a prescribed, non-chemotherapy oral medication that is intended to treat those who have been diagnosed with HR+ and HER2- metastatic breast cancer when taken regularly as ordered. An Emmy Award winning actress, Khrystyne started as a fashion model at age 14, appearing on magazine covers and billboards world-wide, soon after progressing to commercials, starring roles in Network TV movies & series, Best known for the role of Simone, on ABC's 5-year top 20 hit Head of the Class. An official website of the United States government, : Under the approval, patients' cancers must have spread to . The findings reported at the San Antonio meeting included a 3-month update of a planned early (interim) analysis of the trial published in September. This site uses cookies to provide you with a great user experience. commercials discovery of songs/actors/girl/boy. Check out our FAQ Page. Breaking any of the sub's rules may result in a post/comment removal and possibly a temporary or permanent ban, depending on the severity of the offense or in the event of repeat offenses. The 35-year-old lady was born in Tashkent, Uzbek Soviet Socialist Republic, USSR, on March 8, 1987. The most common adversereactions(20%)werediarrhea, infections, neutropenia, fatigue, leukopenia, nausea, anemia, and headache. Welcome, @slapshotmary. Resources for Information | Approved Drugs, (RTOR) pilot program,which streamlined data submission prior to the filing of the entire clinical application,andthe, submission from the applicant to facilitatetheFDAs assessment, Healthcare professionals should report all serious adverse events suspected to be associated with the use of any medicine and device to FDAs, For assistance with single-patient INDs for investigational oncology products, healthcare professionals may contact OCEs. Check out our FAQ Page. To participate in the monarchE trial, participants had to have evidence of cancer in the lymph nodes nearest to their tumor, as well as at least one of several other disease characteristics linked to an increased risk of the cancer recurring. UPDATE: On October 12, 2021, the Food and Drug Administration (FDA) approved abemaciclib (Verzenio) in combination with endocrine therapy (either an aromatase inhibitor or tamoxifen) following surgery to treat some people with HR-positive, HER2-negative breast cancer. Once verified, the information you provide will be displayed on our site. By using iSpot.tv, you accept our, Real-Time Ad Measurement Across Linear and CTV, Marketing Stack Integrations and Multi-Touch Attribution. Have questions about this ad or our catalog? "On October 12, 2021, the Food and Drug Administration (FDA) approved abemaciclib (Verzenio) in combination with endocrine therapy (either an aromatase inhibitor or tamoxifen) following surgery to treat some people with HR-positive, HER2-negative breast cancer. Verzenio try to promote products Verzenio through Relentless Birthday Party and Anniversary Verzenio TV advertisement 2021. Verzenio is a prescribed, non-chemotherapy oral medication intended to treat those who have been diagnosed with HR+ and HER2- metastatic breast cancer when taken regularly as ordered. Competition for Verzenio includes Keytruda, IBRANCE, Opdivo, Neulasta, Incyte and the other brands in the Pharmaceutical & Medical: Rx: Cancer industry. Its not approved to treat early-stage breast cancerbut, according to Eli Lilly, the company recently filed for that approval. An Emmy Award winning actress, Khrystyne started as a fashion model at age 14, appearing on magazine covers and billboards world-wide, soon after progressing to commercials, starring roles in Network TV movies & series, Best known for the role of Simone, on ABC's 5-year top 20 hit Head of the Class. Your email address will not be published. On October 12,2021, the Food and Drug Administration approved abemaciclib (Verzenio,Eli Lilly and Company)with endocrine therapy (tamoxifen or an aromatase inhibitor) for adjuvant treatment of. Download the 2023 Super Bowl TV Ad Report from iSpot Today. The chances of the cancer returning under this general treatment approach are modest. Check out our FAQ Page. No information which song is used in the Verzenio TV commercial ad Relentless Birthday Party and Anniversary. By using iSpot.tv, you accept our. IDFS at 36 months was 86.1% (95% CI: 82.8, 88.8) for patients receiving abemaciclib plus tamoxifen or an aromatase inhibitor and 79.0% (95% CI: 75.3, 82.3) forthosereceiving tamoxifen or an aromatase inhibitor. Overall survival data were not mature at the time of the IDFS analysis. . But longer follow-up [of study participants] is crucial, Dr. ORegan stressed during an SABCS session on the trials findings. Follow theOncology Center of Excellenceon Twitter@FDAOncology. Eucerin TV Commercials. Before sharing sensitive information, make sure you're on a federal government site. Actors in Verzenio Relentless Birthday Party and Anniversary Commercial 2021 Actors/Actress in Verzenio commercial Relentless Birthday Party and Anniversary. The .gov means its official.Federal government websites often end in .gov or .mil. Dr. Osborne agreed that longer follow-up of monarchE participants will be important, particularly sincethe cancer in people with early-stage disease can return 5 or 10 years after theyve completed treatment. Submit ONCE per commercial, and allow 48 to 72 hours for your request to be processed. Verzenio is a prescribed, non-chemotherapy oral medication intended to treat those who have been diagnosed with HR+ and HER2- metastatic breast cancer when taken regularly as ordered. The vast majority experienced no return of their cancer during the short time they were followed. In the past 30 days, Eucerin has had 2,098 airings and earned an airing rank of #521 with a spend ranking of #881 as compared to all other advertisers. Many trial participants also received some form of adjuvant chemotherapy. Michelob ULTRA Super Bowl 2019 TV Spot, 'Robots' Featuring Maluma, TurboTax TV Spot, 'New Job' Featuring David Ortiz, Visit California TV Spot, 'Spoiled in California' Featuring Dax Shepard, Tyler Florence, The Home Depot TV Spot, 'Bells and Whistles', Michelob ULTRA TV Spot, 'Robots' con Maluma [Spanish], This site uses cookies to provide you with a great user experience. Under the approval, patients cancers must have spread to nearby lymph nodes and exhibit certain traits that make the cancer more likely to come back, including high levels of a protein called Ki-67. Participants were assigned at random to receive standard adjuvant hormone therapy alone or in combination with abemaciclib. by Elia Ben-Ari, December 22, 2022, Verzenio works inside the cell to block CDK4/6 activity and help stop the growth of cancer cells, so they may eventually die (based on preclinical. Verzenio is a prescribed, non-chemotherapy oral medication intended to treat those who have been diagnosed with HR+ and HER2- metastatic breast cancer when taken as directed. The studys lead investigator, Priya Rastogi, M.D., of the University of Pittsburgh Department of Medicine, reported the findings on December 9 at the San Antonio Breast Cancer Symposium (SABCS). Published June 02, 2021 Advertiser Verzenio Advertiser Profiles Facebook, Twitter Products Verzenio Songs - Add None have been identified for this spot Phone 1-844-VERZENIO Ad URL http://www.verzenio.com Mood There is an unmet need for new treatment options for patients with high-risk disease, Dr. Rastogi said. Based on their effectiveness in treating advanced breast cancer, several clinical trials were launched to see if CDK4/6 inhibitors might fill a treatment gap for people with high-risk early-stage breast cancer. By using iSpot.tv, you accept our, Real-Time Ad Measurement Across Linear and CTV, Marketing Stack Integrations and Multi-Touch Attribution. On October 12,2021, the Food and Drug Administration approved abemaciclib (Verzenio,Eli Lilly and Company)with endocrine therapy (tamoxifen or an aromatase inhibitor)for adjuvant treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-positive, early breast cancer at high risk of recurrence and a Ki-67 score 20%, as determined by an FDA approved test. Camden Singer Actress | Annabelle Camden Singer is known for Annabelle (2014), The Levenger Tapes (2013) and The Mentalist (2008). Competition for Eucerin includes Proactiv, Olay, Gold Bond, Neutrogena (Skin Care), Cicatricure and the other brands in the Health & Beauty: Skin & Foot Care industry. Blood clots and lung inflammation, both of which can be fatal, occurred in fewer than 3% of people in the abemaciclib group, compared with fewer than 1% in the hormone therapyonly group. I hate it. You can connect with Eucerin on Facebook, Twitter and YouTube. View full prescribing information forVerzenio. Along with the nearly 30% reduction in the risk of developing invasive cancerin participants who received abemaciclib (called invasive disease-free survival), there was also a similar decrease in the risk of cancer returning as metastatic disease (called distant relapse-free survival). Bariatric Surgery May Reduce Risk of Common Cancers, U.S. Department of Health and Human Services, 2-Year Invasive Disease-Free Survival High Ki-67. Abemaciclib is currently approved by FDA to treat advanced or metastatic breast cancer (alone and in combination with an aromatase inhibitor). Have questions about this ad or our catalog? The FDA today greenlit Verzenio for the adjuvant treatment of patients with HR-positive, Her2-negative, node-positive breast cancer at high risk of recurrence . By using iSpot.tv, you accept our. Solutions . Check out our FAQ Page. Press J to jump to the feed. Some of the more common side effects . This is "Verzenio: Family of Three Commercial 2020" by Khrystyne Haje on Vimeo, the home for high quality videos and the people who love them. Chest pain. Thats important, he said, because when these drugs are used in people with advanced cancer, there have been some reports that tumors seem to grow faster when you stop [treatment].. Create and promote branded videos, host live events and webinars, and more. Submit ONCE per commercial, and allow 48 to 72 hours for your request to be processed. Verzenio is the first medication of its class to be approved for EBC. Another factor that doctors have begun to use in this risk calculation is the percentage of tumor cells in a biopsy sample that express the Ki-67 protein, which is associated with cell division. 2. The site is secure. The approval was based on 3-year survival results from the monarchE trial (described below). Overall, the more than 5,600 participants in the trial had good survival outcomes regardless of whether they received abemaciclib. Once verified, the information you provide will be displayed on our site. Employee communication. by Sharon Reynolds, National Cancer Institute Her parents are Soviet-era Jewish refugees, and her career as a child actor kicked off shortly after coming to America. Participants in the trial who received abemaciclib for 2 years along with standard postsurgical, or adjuvant, hormone therapy were about 30% less likely to have their cancer come back in an invasive form than participants who received the standard adjuvant hormone therapy alone. The two others are palbociclib (Ibrance) and ribociclib (Kisqali). And thats where abemaciclib entered the picture. by Carmen Phillips. Published January 10, 2022 Advertiser Verzenio Advertiser Profiles Facebook, Twitter Products Verzenio Tagline "Every Day Matters" Songs - Add On October 12, 2021, the FDA approved abemaciclib (brand name Verzenio) with endocrine therapy (tamoxifen or an aromatase inhibitor) for adjuvant treatment of adult patients with hormone receptor . I hate her with the fire of a thousand suns. In addition to the 40-plus AT&T ads she's . Verzenio is a medication that when taken as prescribed is intended to help treat those diagnosed with HR+ and HER2- metastatic breast cancer. Download the 2023 Super Bowl TV Ad Report from iSpot Today. Required fields are marked *. Verzenio encourages women diagnosed with MBC to be relentless and talk to their doctor about its product, which, when taken regularly as directed, may delay disease progression. In addition, the Penelope-B trial results covered a median of 4 years of patient follow-up. Verzenio First Watch. For assistance with single-patient INDs for investigational oncology products, healthcare professionals may contact OCEsProject Facilitateat240-402-0004 or emailOncProjectFacilitate@fda.hhs.gov. Verzenio encourages women diagnosed with MBC to be relentless and talk to their doctor about its product, which, when taken regularly as directed, may delay disease progression. Verzenio is a prescribed, non-chemotherapy oral medication intended to treat those who have been diagnosed with HR+ and HER2- metastatic breast cancer when taken as directed. Submissions should come only from actors, their parent/legal guardian or casting agency. by Carmen Phillips, December 2, 2022, But some significant unknowns remain, Dr. Korde added. Mirror TV Spot, 'You're Not Alone' Song by Nvdes, Domino's TV Spot, 'Pizza Pit Stop' Featuring Denny Hamlin, This site uses cookies to provide you with a great user experience. Walt and Jesse, PopCorners Breaking Bad Super Bowl 2023 Commercial Feat. The median patient follow-up thus far in the trial is approximately 19 months, and only about a quarter of participants have completed 2 years of adjuvant therapy. Your email address will not be published. at the National Institutes of Health, An official website of the United States government, Trial Tests Abemaciclib As New Option for Early-Stage Breast Cancer, about 30% less likely to have their cancer come back in an invasive form, Division of Cancer Treatment and Diagnosis, planned early (interim) analysis of the trial published in September, called Penelope-B, also were presented at SABCS, Drug Targets Common Mutation in Pancreatic Cancer. . The recommendedabemaciclibstartingdoseis150 mg taken twice daily in combination withtamoxifen or an aromatase inhibitoruntil completion of 2 years of treatment or until disease recurrence, or unacceptable toxicity. However, Dr. ORegan pointed out that, after 2 years of follow-up in the trial, the magnitude of the difference in invasive disease-free survival between the treatment groups was very similar to the difference reported in monarchE. As with any therapy, I think the risks of the drugs need to be carefully weighed against the risk of recurrence, she said. What else you know her from Since exploding onto the scene in 2013 as a bubbly AT&T employee named Lily, Vayntrub has become a recognizable actor. Verzenio TV Commercials We don't make the ads - We measure them Sign up to track 16 nationally aired TV ad campaigns for Verzenio. What Causes Immunotherapys Heart-Related Side Effects? Save my name, email, and website in this browser for the next time I comment. Submit ONCE per commercial, and . The development of metastatic cancer is an important indicator for people with early-stage breast cancer, Dr. Korde said, because when it returns in another part of the body, such as the liver or lungs, the cancer is no longer considered to be curable. Submit ONCE per commercial, and allow 48 to 72 hours for your request to be processed. Only includes the 2,498 patients for which Ki-67 was assessed at a central laboratory. Submissions should come only from actors, their parent/legal guardian or casting agency. In addition, he noted that CDK4/6 inhibitors are thought to work by stopping or slowing the growth of cancer cells, not by killing them. Abemaciclib is one of three drugs approved by the Food and Drug Administration (FDA) that block the activity of two proteins on cancer cells, CDK4 and CDK6. New comments cannot be posted and votes cannot be cast. Verzenio can harm your unborn baby. FDA also approved a companion diagnostic test called Ki-67 IHC MIB-1 pharmDx for this indication. Healthcare professionals should report all serious adverse events suspected to be associated with the use of any medicine and device to FDAsMedWatch Reporting Systemor by calling 1-800-FDA-1088. One could argue that in a very high-risk population, the potential benefit outweighs the risk, but I think this decision needs to be made on an individual basis., The Cancer Moonshot: A Midpoint Progress Update, If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. In the past 30 days, Verzenio has had 117 airings and earned an airing rank of #1,861 with a spend ranking of #993 as compared to all other advertisers. And most of those who changed to a reduced dose or skipped doses of the drug have been able to continue taking it, she said. This site uses cookies to provide you with a great user experience. Although the available therapies for this type of breast cancer are very effective, a portion of patients are at particularly high risk of their cancer returning, or relapsing, in the years following treatment. However, this markercalled the Ki-67 indexis not routinely determined for all patients. r/CommercialsIHate . Verzenio Relentless Birthday Party and Anniversary commercial is the newest 2021 TV commercial ad of Verzenio, also known as Relentless Birthday Party and Anniversary commercial 2021, Verzenio Relentless Birthday Party and Anniversary advert 2021, Verzenio TV spot Relentless Birthday Party and Anniversary, Verzenio TV commercial Relentless Birthday Party and Anniversary. Verzenio Relentless Birthday Party and Anniversary commercial song. Use effective birth control (contraception) during treatment and for 3 weeks after the last dose of Verzenio and do not breastfeed during treatment with Verzenio and for at least 3 weeks after your last dose. 3. Verzenio is a non-chemotherapy oral tablet. Largely due to advances in treatment over the past several decades, the long-term prognosis for people diagnosed with early-stage, HR-positive, HER2-negative cancer is generally very good. Adrienne LaValley Actress | Transcending: The Beginning of Josephine Adrienne LaValley is known for Transcending: The Beginning of Josephine (2016), Alien Opponent (2010) and Insidious (2008). In the past 30 days, Eucerin has had 2,098 airings and earned an airing rank of #521 with a spend ranking of #881 as compared to all other advertisers. in combination with endocrine therapy (tamoxifen or an aromatase inhibitor) for the adjuvant treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-positive, early breast cancer at high risk of recurrence and a Ki-67 score 20% as determined by an FDA approved test.